In Synthesis Partners’ supply chain research covered here, a gap is defined as a constraint or bottleneck that limits the growth of technology development and manufacturing supply chains in North America (NA). Such gaps are based on factors that are largely under the control of R&D, advanced manufacturing and technology investment organizations (i.e., the gaps are susceptible to technology development processes, factors or forces). Our focus is not on external market factors (e.g., demand weakness, currency valuation or status of trade agreements) — even though these are significant variables in supply chain development. For example, in the context of this work a gap may be a technology performance limitation or an engineering design issue that can be addressed by NA suppliers. A solution that can boost the NA supply chain’s capability, increase American competitiveness and accelerate high-value job creation is of interest. The focus of our work is on identifying concrete opportunities for US-based R&D and technology investment organizations to accelerate the development of specific technologies, processes or systems needed in NA supply chains.